Nuclear and Cytoplasmic Location of the FER Tyrosine Kinase

Qian-Lin Hao1 Section of Molecular Diagnosis, Department of Pathology, Childrens Hospital of Los Angeles, 4650 Sunset Boulevard, Los Angeles, California90027

Douglas K. Ferris2 Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21701

Gretchen White2 Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21701

Nora Heisterkamp1 Section of Molecular Diagnosis, Department of Pathology, Childrens Hospital of Los Angeles, 4650 Sunset Boulevard, Los Angeles, California90027

John Groffen1 Section of Molecular Diagnosis, Department of Pathology, Childrens Hospital of Los Angeles, 4650 Sunset Boulevard, Los Angeles, California90027

Abstract

The location of the FER protein within the cell was investigated by using subcellular fractionation and immunofluorescence. FER was found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes.

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Nuclear and Cytoplasmic Location of the FER Tyrosine Kinase

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Nuclear and Cytoplasmic Location of the FER Tyrosine Kinase

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