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Molecular and Cellular Biology Volume 7, 1987 - Issue 8
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Research Article

Chromosome-Mediated Transfer of the Murine Na,K-ATPase Alpha Subunit Confers Ouabain Resistance

Dorothy Fallows1 Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Rachel B. Kent1 Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
David L. Nelson1 Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Janet Rettig Emanuel2 Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut06510
,
Robert Levenson2 Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut06510
&
David E. Housman1 Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
Pages 2985-2987 | Received 12 Dec 1986, Accepted 11 May 1987, Published online: 31 Mar 2023
 
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Abstract

We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase α1 subunit gene was detected, suggesting that structural differences between the rodent and primate α1 subunits determine the different ouabain sensitivities.

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