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Molecular and Cellular Biology Volume 8, 1988 - Issue 8
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Research Article

The Carboxy-Terminal Sequence of p56lck Can Regulate p60c-src

Alasdair MacAuley1 Department of Cell Biology, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington98104
&
Jonathan A. Cooper1 Department of Cell Biology, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington98104
Pages 3560-3564 | Received 30 Mar 1988, Accepted 18 May 1988, Published online: 31 Mar 2023
 
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Abstract

A chimera containing the coding region for residues 1 to 516 of p60c-src and residues 495 to 509 (the carboxy terminus) of p56lck was constructed and expressed in mouse fibroblasts. The chimeric protein appeared to be phosphorylated and regulated in the same fashion as p60c-src.

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