In Vitro Osteogenesis of Synovium Mesenchymal Cells Induced by Controlled Release of Alendronate and Dexamethasone from a Sintered Microspherical Scaffold

Yingjun Wang School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, P. R. China; Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore., Email: [email protected]

Xuetao Shi School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, P. R. China, Key Laboratory of Specially Functional Materials and Advanced Manufacturing Technology, South China University of Technology, Ministry of Education, Guangzhou 510641, P. R. China

Li Ren School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, P. R. China, Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore

Yongchang Yao Key Laboratory of Specially Functional Materials and Advanced Manufacturing Technology, South China University of Technology, Ministry of Education, Guangzhou 510641, P. R. China

Dong-An Wang Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore, Key Laboratory of Specially Functional Materials and Advanced Manufacturing Technology, South China University of Technology, Ministry of Education, Guangzhou 510641, P. R. China

Abstract

In vitro osteogenesis was successfully achieved with synovium-derived mesenchymal stem cells (SMSCs), which intrinsically have a strong chondrogenic tendency, by in situ release of alendronate (AL) and dexamethasone (Dex) from poly(lactic-co-glycolic acid) (PLGA)/hydroxyapatite (HA) sintered microspherical scaffold (PLGA/HA-SMS). Cumulative release profiles of AL and Dex from PLGA/HA-SMS and the influence on SMSCs osteogenic commitment were investigated. SMSCs seeded in Al-/Dex-loaded PLGA/HA-SMS (PLGA/HA-Com-SMS) exhibited significant osteogenic differentiation, as indicated by high yields of alkaline phosphatase (ALP) and bone calcification. In addition, mechanical properties (compressional) of PLGA/HA-Com-SMSs were also evaluated and approved. In conclusion, by promoting osteogenic commitment of SMSCs in vitro, this newly designed controlled-release system opens a new door to bone reparation and regeneration.

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In Vitro Osteogenesis of Synovium Mesenchymal Cells Induced by Controlled Release of Alendronate and Dexamethasone from a Sintered Microspherical Scaffold

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In Vitro Osteogenesis of Synovium Mesenchymal Cells Induced by Controlled Release of Alendronate and Dexamethasone from a Sintered Microspherical Scaffold

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