Development of Swellable Local Implants of a Polyethyleneimine-Poly(Vinyl Pyrrolidone) (PEI-PVP) Hydrogel as a Socket Filler

Abstract

In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cytotoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI–PVP hydrogels were examined in male beagles and compared to values using Spongostan^®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI– PVP hydrogels or Spongostan^®. In the in vivo study, PEI–PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan^®. In conclusion, PEI–PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI–PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.

Keywords:

• Polyethyleneimine
• poly(vinyl pyrrolidone)
• socket filler
• hydrogel

Acknowledgements

The authors sincerely appreciate the grant support from the National Science Council (NSC94-2320-B-038-012) and Department of Health, Executive Yuan (DOH100-TD-B-111-003, Center of Excellence for Clinical Trial and Research in Neuroscience), ROC.

Notes

aBeagles were the experimental animal.

bDissolution, USP XXIV paddle method.

cFranz diffusion cell with deionized water, 0.9% NaCl and saliva in the donor site.