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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 26, 2004 - Issue 3
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Articles

Neomycin inhibits glioma cell migration

Pedro CuevasDepartamento de InvestigaciónHospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain and Department of Neurosurgery, Wayne State University, Detroit MI, USA
,
Diana Díaz-GonzálezDepartamento de InvestigaciónHospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
&
Manuel DujovnyDepartment of NeurosurgeryWayne State University, Detroit MI, USA
Pages 273-275 | Published online: 19 Jul 2013
 
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Abstract

Blocking migration is an attractive strategy to inhibit glioma tumorigenesis. Previous studies have indicated that neomycin inhibits glioma cells proliferation. The purpose of this study was to expand on the preliminary research by investigating the antimigratory effect of neomycin. Weused glioma C6 cells to investigate the role of neomycin in cell migration in vitro. Cell wounding assay showed that neomycin inhibits in a dose-dependent manner glioma cells migration into the wound. Taken together, these results suggest that neomycin is an attractive candidate for the development of novel antimigratory molecules useful for the treatment of gliomas.

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