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Annals of Tropical Medicine & Parasitology Volume 105, 2011 - Issue 6
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Original Article

Lack of association between blood-based detection of Trypanosoma cruzi DNA and cardiac involvement in a non-endemic area

F F Norman Tropical Medicine and Clinical ParasitologyInfectious Diseases Department, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Km. 9, Madrid28034, SpainCorrespondence[email protected]
,
A Pérez-Ayala Tropical Medicine and Clinical ParasitologyInfectious Diseases Department, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Km. 9, Madrid28034, Spain
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J A Pérez-Molina Tropical Medicine and Clinical ParasitologyInfectious Diseases Department, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Km. 9, Madrid28034, Spain
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M Flores-Chavez Servicio de ParasitologíaCentro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera de Majadahonda-Pozuelo Km. 2, Madrid28220, Spain
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C Cañavate Servicio de ParasitologíaCentro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera de Majadahonda-Pozuelo Km. 2, Madrid28220, Spain
&
R López-Vélez Tropical Medicine and Clinical ParasitologyInfectious Diseases Department, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Km. 9, Madrid28034, Spain
Pages 425-430 | Received 11 Nov 2010, Accepted 27 Jul 2011, Published online: 22 Nov 2013
 
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Abstract

Cases of chronic Chagas disease have been increasing in non-endemic areas due to the growth in immigration. This study examined the association between positive Trypanosoma cruzi-DNA detection in blood by PCR and presence of chagasic cardiac involvement in a cohort of immigrants in a European city. No association was found in this study between the positive T. cruzi blood PCR and cardiac involvement.

ACKNOWLEDGMENTS.We would like to thank Ms L. Moreno and the staff at the Tropical Medicine Unit and parasitology laboratory for technical assistance.

This study was supported by the Spanish Ministry of Science and Innovation and the Instituto de Salud Carlos III within the Network of Tropical Diseases Research (RICET RD06/0021/0020 and RD06/0021/0009).

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