Mesoporous bioactive glass: ideal material for higher uptake and well sustained release of ibuprofen

Abstract

Mesoporous bioactive glass (MBG) and mesoporous silica (MS) have been synthesised by evaporation induced self-assembly method. Both samples possess ordered mesoporous structure and grainy morphologies. Ibuprofen was used as model drug, and the drug loading and release process were studied in detail. The MBG shows a higher drug loading capacity (46%) than that of MS (28%) due to its high surface area and pore volume and the stronger interaction between ibuprofen and Ca²⁺ of MBG. The release profile investigation of both samples indicated that MBG has a longer and gentle drug release process than that of MS. It can be found that MBG has the advantages for controlled release, such as higher drug loading capacity and long release effect, which makes MBG a good candidate for drug carrier.

Keywords:

• Mesoporous bioactive glass
• Mesoporous silica
• EISA process
• Drug release

Financial support for this study was provided by the National Native Science Foundation of China (20871037, 21171045, 21101046), Innovation special fund of Harbin Science and Technology Bureau of China (2010RFXXS055), Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang province (2011TD010), and Doctoral Initiation Fund of Harbin Normal University (KGB201006).