Development and evaluation of olmesartan medoxomil loaded PLGA nanoparticles

Abstract

The purpose of the present study was to develop olmesartan medoxomil (OLM) loaded poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles by nanoprecipitation technique. Olmesartan medoxomil nanoparticles (F1–F3) were prepared using PLGA as polymer and Pluronic acid 127 as a surfactant. Developed PLGA nanoparticles were evaluated for particle size, polydispersity index (PI), differential scanning calorimetry (DSC), Fourier transforms infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), drug entrapment efficiency (EE%) and in vitro drug release. Optimised PLGA nanoparticle (F3) had particle size of 97.8 ± 6.3 nm, EE of 58.33% and drug release of 37.1% after 24 h of study. SEM images confirmed that developed nanoparticles were spherical in shape with a smooth surface. DSC, FTIR, and XRD spectra indicated formation of PLGA nanoparticles. The results suggest that PLGA polymer-based nanoparticle could be a potential option for sustained drug delivery of OLM.

Keywords:

• Polymer
• Nanoparticle
• Particle size
• Drug entrapment
• Olmesartan medoxomil
• SEM

Acknowledgement

The authors are thankful to Department of Pharmaceutics, College of Pharmacy, Salman Abdulaziz University, Al-kharj, Saudi Arabia for providing essential facility in this research.