Response of neural precursor cells in the brain of Parkinson's disease mouse model after LIF administration

Abstract

Objective: To access the response of endogenous neural precursor cells (NPCs) in the area of substantia nigra (SN) in the mouse model of Parkinson's disease (PD). To evaluate whether leukemia inhibitory factor (LIF) can up-regulate the expression of NPCs and their fate in differentiation.

Methods: NPCs were measured and the number and density were estimated using the confocal counting system in normal control (CON), normal control LIF treated (CON + LIF), PD (PD) and LIF treated PD (PD + LIF) mice.

Results: The PD + LIF group showed a statistically significant improvement in the number and density of NPCs compared with PD group, and NPCs are rarely seen in CON and CON + LIF groups.

Conclusion: LIF may be a useful treatment for PD by up-regulating the re-expression of NPCs, which may represent the neuroprotection mechanism of LIF.

Keywords:

• PARKINSON'S DISEASE
• NEURAL PRECURSOR CELLS
• DIFFERENTIATION
• LEUKEMIA INHIBITORY FACTOR