Mutations in GBA and risk of Parkinson’s disease: a meta-analysis based on 25 case-control studies

Abstract

The association between glucocerebrosidase (GBA) mutations and Parkinson’s disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the relationship between the most common GBA mutations, L444P and N370S and PD susceptibility, an updated meta-analysis was performed by searching PUBMED, EMBASE, MEDLINE, and EBSCO databases. Twenty five studies including 9, 599 cases and 13, 541 controls were collected in the end. The summary of odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using fixed- and random-effects models, when appropriate. Overall, our meta-analysis provided evidence that both were risk factors associated with increased PD susceptibility. When stratified by ethnicities, the associations varied among different ethnical origins.

Keywords:

• Parkinson’s disease
• Glucocerebrosidase
• Mutation
• Meta-analysis

We gratefully acknowledge Professor Rong Peng for her help in preparing the manuscript and Professor Bo Wu for his help in revising the manuscript. We also thank all the study participants.