![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objectives:
We evaluated the rupture risk of multiple cerebral aneurysms in aspects of various morphological parameters, and determined which parameter can be a reliable predictor as one aneurysm ruptured, and the others did not.
Methods:
Between 2007 and 2012, three-dimensional (3D) angiographic images of 85 patients harboring multiple aneurysms (85 ruptured and 104 unruptured aneurysms) were used to assess the following morphological parameters: geometry of the aneurysm itself, e.g. maximal size, aspect ratio, bottleneck ratio, height/width ratio, undulation, and daughter sac; architecture of the aneurysm and surrounding vessels, e.g. aneurysmal angle, vessel angle, inflow angle, parent–daughter angle, and size ratio type I & II. Univariate analysis was applied to all parameters, and significant parameters were identified in multivariate analysis, yielding the cut-off point from receiver-operating characteristic (ROC) curve analysis.
Results:
On multivariate logistic regression, the aspect ratio [odds ratio (OR), 1·21; 95% confidence interval (CI), 1·05–1·41] and daughter sac (OR, 3·12; 95% CI, 1·05–9·27) were significant parameters in geometries of the aneurysm itself. The size ratio type I (OR, 1·14; 95% CI, 1·05–1·22) and parent–daughter angle (OR, 1·02; 95% CI, 1·00–1·04) were independent parameters in architecture of the aneurysm and surrounding vessels. From the ROC curve, the aspect ratio and size ratio type I had cut-off values of 1·3 and 1·8, respectively.
Conclusion:
Several morphological parameters were investigated to predict a rupture in multiple cerebral aneurysms using 3D angiogram. The aspect ratio, size ratio type I, daughter sac, and parent–daughter angle were revealed as competent parameters.