Ornidazole containing sterculia gum based hydrogels for use in drug delivery

Abstract

The present study deals with the modification of sterculia gum with 2-hydroxyethylmethacrylate and acrylic acid via network formation meant for the drug delivery system using ammonium persulphate as initiator and N,N′-methylenebisacrylamide as cross-linker. Polymeric networks (hydrogels) were characterised with SEMs, Fourier transform infrared spectroscopy, thermogravimetric analysis and swelling studies. This paper discusses the swelling of the hydrogels and release dynamics of antidiarrhoea model drug ornidazole from the hydrogels for the evaluation of swelling and drug release mechanism. The diffusion of drug occurred through the non-Fickian diffusion mechanism from the hydrogels. This dietary fibre based drug delivery system after degradation of hydrogels and release of drug in gastrointestinal tract may exert the synergic effect, and the present drug delivery system may act with double potential to cure diarrhoea.

Keywords:

• Antidiarrhoea drug
• Ornidazole
• Hydrogels
• Drug delivery