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Original Article

Titanium oxide films with vacuum thermal treatment for enhanced hemocompatibility

, , , , , & show all
Pages 898-903 | Received 11 Aug 2014, Accepted 02 Sep 2014, Published online: 15 Sep 2014
 

Abstract

Blood compatibility is a key property of biomaterials contacting blood. Titanium oxide film has been deposited on Si wafers (110) by unbalanced reactive magnetron sputtering and successive vacuum annealing. The structure, chemical composition, hydrophilicity and surface energy of the films have been investigated by X-ray diffraction, X-ray photoelectron spectroscopy and contact angle measurement respectively. The results revealed that high vacuum annealing increased the surface energy, hydrophilicity and the rate of of Lewis base in the film. In vitro evaluation of hemocompatibility, including platelet adhesion, fibrinogen denaturation, activated partial thromboplastin time and thrombin time test, proved that the hydrophilic titanium oxide films have excellent blood compatibility.

Acknowledgement

This work was financially supported by the National Science Foundation of China (grant nos. 9732011CB606200, 81330031 and 81401522).

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