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Abstract
In this paper, a simple, highly sensitive, and cost-effective method was described for cocaine detection as an example in the stimulants using an aptamer-functionalised gold nanoparticles (Au NPs). Cocaine-specific aptamer is single-strand DNA sequence that can specifically bind to cocaine. Carboxyfluorescein (FAM)-labelled aptamer was adsorbed on the surface of Au NPs. Then FAM was quenched owing to the close proximity between aptamer and Au NPs. Cocaine can be detected after the fluorescence of FAM was restored by detaching from the surface of Au NPs. The limit of detection (LOD) was 3 pM. The results show this sensitive method is promising for the detection of stimulants.