Daptomycin serum levels in critical patients undergoing continuous renal replacement

Abstract

Background: Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT).

Methods: The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin therapy. Daptomycin was measured using an isocratic high-performance liquid chromatography technique.

Results: Three patients with bloodstream infection underwent CVVHD and three CVVHDF. CVVHDF patients had significantly lower mean AUC₀₋₂₄ and C_max values. A significant decrease in plasma levels was observed in a CVVHDF patient using ‘high cut-off’ hemofilters.

Conclusion: Increasing doses of daptomycin should be considered in critical patients, especially those undergoing CVVHDF.

Keywords:

• Daptomycin
• Pharmacokinetic
• Continuous renal replacement therapy
• Intensive care unit
• Staphylococcal infections

This study was funded by the Italian Ministry of Health, Progetto di Ricerca di Interesse Nazionale (PRIN) no. MIUR – PRIN 20087SM5HM.