Controversies in preventive therapy for children contacts of multidrug-resistant tuberculosis

Abstract

Background: Drug-resistant tuberculosis (DR-TB) is emerging as an increasing problem worldwide and no consensus has been reached about the management of children contacts of DR-TB cases.

Objective: To evaluate the role of post-exposure chemoprophylaxis in paediatric DR-TB contacts, focusing on literature findings and recommendations from existing international guidelines.

Methods: We conducted a literature search of the Cochrane Library, MEDLINE by PubMed and EMBASE from database inception through September 2012, using an appropriate search strategy.

Results: Eighteen articles were included: four retrospective and two prospective population studies, eight international guidelines and four narrative reviews.

Conclusions: general agreement exists that preventive therapy could be beneficial in specific high-risk groups, including immunocompromised children and those aged < 5 years. However, no consensus exists on the use of preventive therapy in older or immunocompetent children and on which regimen should be preferred.

Keywords:

• Children
• IGRA
• Multidrug-resistant
• TB-contact
• Tuberculosis