Population pharmacokinetics of levofloxacin in Korean patients

Abstract

Levofloxacin (LVFX) has different effects depending on the area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ratio. While AUC can be expressed as dose/clearance (CL), we measured serial concentrations of LVFX in Koreans and tried to set a Korean-specific equation, estimating the CL of the antibiotic. In total, 38 patients, aged 18–87 years, received once daily intravenous LVFX doses of 500 mg or 250 mg, depending on their renal function. Four plasma samples were obtained according to a D optimal sampling design. The population pharmacokinetic (PK) parameters of LVFX were estimated using non-linear mixed-effect modeling (NONMEM, ver. 7.2). The CL of LVFX was dependent on creatinine clearance (CL_CR) as a covariate. The mean population PK parameters of LVFX in Koreans were as follows: CL (l/hour) = 6.19 ×  (CL_CR/75)^1.32. The CL of LVFX in Koreans is expected to be lower than that in Western people.

Keywords:

• Levofloxacin
• Population pharmacokinetics
• Clearance
• Area under the concentration curve