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Anticancer Original Research Paper

Experimental study of antitumour activity and effects on leukocyte count of intraperitoneal administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet in a rat model of ovarian cancer

, , , , , , , , & show all
Pages 203-209 | Received 19 Feb 2015, Accepted 08 Apr 2015, Published online: 14 Jul 2016
 

Abstract

Survival of rats with advanced ovarian cancer after intraperitoneal (i.p.) administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet and effects of these treatment modalities on leukocyte count were evaluated in two independent series of experiments. Hyperthermic intraperitoneal chemoperfusion with dioxadet (15 mg/kg) provided median survival of rats of 49 days (95% CI 28–70), i.p. administration of dioxadet (1.5 mg/kg) of 28 days (95% CI 16–36; P = 0.020). Single i.p. injection of dioxadet caused a significant decrease in total number of leukocytes (17–52%), granulocytes (18–75%), lymphocytes (18–62%) and monocytes (12–46%) in the peripheral blood of tumour-bearing rats compared to untreated animals. After HIPEC with dioxadet, the total number of leukocytes, granulocytes, lymphocytes and monocytes in peripheral blood of rats remained significantly higher than the corresponding values in the group with dioxadet.

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