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Journal of Chemotherapy Volume 28, 2016 - Issue 5
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Letter to the Editor

Detection and characterization of OXA-48-producing Klebsiella pneumoniae originated in Bulgaria

Stefana SabtchevaLaboratory for Clinical Microbiology, National Oncology Center – SHATO, Sofia, BulgariaCorrespondence[email protected]
,
Ivan N. IvanovNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
,
Bozhana TodorovaNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
,
Yordan SimeonovDepartment of Surgery, Specialized Hospital for Active Treatment in Oncology – SHATO, Sofia, Bulgaria
,
Elina DobrevaNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
,
Krasimira IvanovaNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
,
Tzvetan VelinovNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
&
Todor KantardjievNational Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria
 show all
Pages 450-453 | Received 15 Feb 2015, Accepted 30 Apr 2015, Published online: 22 Jul 2016
 
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Abstract

We report the identification of OXA-48-producing Klebsiella pneumoniae, causing peritonitis in a cancer patient admitted to the Oncology Hospital in Sofia. The isolate had reduced susceptibility to carbapenems but remained susceptible to extended-spectrum cephalosporins. PCR and sequencing confirmed the presence of blaOXA-48 gene flanked by two intact copies of IS1999 on truncated ΔTn1999.1. This transposon was located on unusual non-typeable 29-kb plasmid that could be transferred only by transformation. Multilocus sequence typing (MLST) indicated the presence of the sequence type ST530.This is the first documented infection due to OXA-48-producing Enterobacteriaceae strain in Bulgaria.

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