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Pathogens and Global Health Volume 107, 2013 - Issue 4
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Short Communication

Efficacy of different albendazole and mebendazole regimens against heavy-intensity Trichuris trichiura infections in school children, Jimma Town, Ethiopia

Z MekonnenDepartment of Medical Laboratory Sciences and PathologyCollege of Public health and Medical Sciences, Jimma University, Ethiopia;Department of VirologyParasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumCorrespondence[email protected]
,
B LeveckeDepartment of VirologyParasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
,
G BouletApplied Molecular Biology Research (AMBIOR) groupLaboratory of Cell Biology and Histology, Antwerp University, Belgium
,
J-P BogersApplied Molecular Biology Research (AMBIOR) groupLaboratory of Cell Biology and Histology, Antwerp University, Belgium
&
J VercruysseDepartment of VirologyParasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Pages 207-209 | Published online: 03 Dec 2013
 
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Abstract

Recent studies have shown that the efficacy of benzimidazole drugs is influenced by the intensity of trichuriasis. Therefore, the objective of this study was to determine the efficacy of albendazole (ALB) and mebendazole (MBZ) administered randomly for 1 (ALB×1 and MBZ×1) or 2 days (ALB×2 and MBZ×2) to 385 school children with heavy-intensity trichuriasis (mean faecal egg counts (FEC) >1000 eggs per gram of stool (epg)) in Jimma Town, Ethiopia. The efficacies (95% confidence intervals) by means of reduction in faecal egg counts (FECs) were 29·3% (−9·9–56·2), 60·0% (48·5–70·9), 73·5% (64·2–81·3), and 87·1% (81·4–91·2) for ALB×1, MBZ×1, ALB×2, and MBZ×2, respectively. These observations highlight that assessment of the anthelmintic efficacy of existing or new compounds against Trichuris trichiura should be assessed under varying levels of infection intensity.

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