Barnidipine real-life tolerability in arterial hypertension: results from the BASIC-HT study

Abstract

Introduction:

Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines.

Objective:

BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting.

Methods:

20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis.

Results:

Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg.

Conclusion:

The decrease in BP, is probably due to stimulation of good adherence by barnidipine.

Keywords:

• Hypertensive patient
• Observational study
• Barnidipine
• Calcium channel blockers
• Persistence