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Abstract
A case of chronic neuropathic pain in the infraorbital region following an untreated displaced zygomatic fracture is presented. The case responded favorably to topiramate and sensory testing revealed signs of nerve damage that remained unchanged over the follow-up period (six months) parallel to an analgesic effect. The clinical pharmacology of topiramate, which is reviewed, includes enhanced neuronal stability and neuroprotection, making it a possible candidate in the treatment of painful orofacial neuropathies.
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Notes on contributors
Rafael Benoliel
Dr. Rafael Benoliel is the chairman of the Department of Oral Medicine, The Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Yair Sharav
Dr. Yair Sharav is a full professor of oral medicine at the School of Dental Medicine, Hebrew University Hadassah, Jerusalem, Israel. He graduated from Hebrew University with a D.M.D. and received a M.S. degree from the University of Illinois. Dr. Sharav is the former chairman of the Department of Oral Diagnosis, Oral Medicine, and Radiology and past Dean of Dental Faculty in Jerusalem. He has been a visiting scientist at the National Instutitutes of Health and visiting professor at the University of Toronto, Canada. He currently acts as director of the Hebrew University Center for Research on Pain.
Eli Eliav
Dr. Eli Eliav received D.M.D. and M.Sc. degrees from the Faculty of Dental Medicine Hebrew University, Hadassah, Jerusalem, Israel. In 1995-1997, he was a visiting fellow in the clinical and basic science research program of the National Institute of Dental and Craniofacial Research, Pain, and Neurosensory Mechanisms Branch, Bethesda, Maryland.