Association of obesity with glucose, blood pressure, and lipid goals attainment in patients with concomitant diabetes and hypertension

Abstract

Objective:

To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension.

Methods and results:

A total of 3041 dyslipidemia patients with an average age of 65.7 ± 10.53 years and comorbid conditions of T2DM and hypertension from the DYSlipidemia International Study (DYSIS) – China were included in the present subgroup analysis. Patients’ demographic data, medication use, blood glucose, and lipid parameters were analyzed retrospectively. Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) differed significantly among participants according to the attainment of treatment targets. Among female patients, significant differences in the rate of target attainment were observed among different WC, WtHR, and BMI quartile groups, whereas no significant differences in goal attainment were found according to WC and WtHR quartiles in male patients. Among the female patients, the results of logistic regression supported a significant association of anthropometric indices and the achievement of targets.

Conclusion:

A considerable proportion of dyslipidemia patients failed to achieve guideline-recommended targets in China, and this apparent treatment gap was more pronounced among women with central adiposity and patients with an elevated BMI. Based on the limitations of this cross-sectional study, further investigation of the mechanism at the molecular level is necessary.

Keywords: :

• Anthropometric indices
• Diabetes
• Dyslipidemia
• Goal attainment
• Hypertension

Transparency

Declaration of funding

This study was funded by a research grant from Merck Sharp & Dohme Co. Ltd. (China). All authors contributed to the intellectual development of this paper.

Declaration of financial/other relationships

Jihu Li has disclosed that she is an employee of MSD China. P.L., K.C., Y.I.N., L.-L.G., H.-B.W., S.-S.W., A.-P.W., D.-Y.H., and Y.-M.M. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.

CMRO peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Acknowledgments

The authors of the present study would like to thank all DYSIS-China investigators for their contribution to the successful completion of this study.