Clinical use of plasma chitotriosidase in severe sepsis

Abstract

Plasma chitotriosidase activity (ChT) was previously proposed to quantify severity of sepsis. In a complex surgical case, with prolonged sepsis and consistently high ChT, we found that the least increased values occurred in stages of extreme illness, with profound hypocholesterolemia. ChT needs better characterization before becoming a reliable biomarker of septic evolution.

Keywords: :

• Critical illness
• Hypocholesterolemia
• Intensive care
• Monitoring
• Plasma chitotriosidase
• Sepsis

Transparency

Declaration of funding

This study was not funded.

Author contributions: C.C. and I.G.: conception and design of project; collection, statistical analysis and interpretation of the data; drafting of the manuscript and final approval of the version to be published. D.A. and A.P.: conception and design of project; laboratory analysis and interpretation of the data; critical revision of the content of the manuscript and final approval of the version to be published. F.A. and F.G.: conception and design of project; interpretation of the data; critical revision of the content of the manuscript and final approval of the version to be published.

Declaration of financial/other relationships

C.C., I.G., D.A., A.P., F.A., and F.G. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.

CMRO peer reviewers on this manuscript have no relevant financial relationships to disclose.