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Summary
The effect of 750 mg. of niflumic acid per day administered orally was studied in 15 patients with active rheumatoid arthritis in a double-blind cross-over trial. The patients were followed over a 2-week period with 3 assessments of joint pain and tenderness, duration and severity of morning stiffness, digital joint circumference, grip strength and radioactive pertechnetate (99m Tc) knee and wrist joint uptakes.
The results show that niflumic acid was more effective in relieving pain than placebo. Anti-inflammatory effects could not be demonstrated.