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Current Medical Research and Opinion Volume 2, 1974 - Issue 6
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Research Article

Clinical Evaluation of Tolmetin

Peter M. Brooks The Centre for Rheumatic Diseases, and University Department of Medicine, Royal Infirmary, Glasgow, Scotland
, M.B., M.R.A.C.P.,
Caroline F. Watkins The Centre for Rheumatic Diseases, and University Department of Medicine, Royal Infirmary, Glasgow, Scotland
,
Roger D. Sturrock The Centre for Rheumatic Diseases, and University Department of Medicine, Royal Infirmary, Glasgow, Scotland
, M.B., M.R.C.P. &
Peter Lee The Centre for Rheumatic Diseases, and University Department of Medicine, Royal Infirmary, Glasgow, Scotland
, M.B., M.R.A.C.P.
Pages 323-328 | Received 06 May 1974, Published online: 04 Aug 2008
 
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Summary

A clinical therapeutic trial of tolmetin in daily doses of 1200 and 1600 mg. is reported in 16 patients with rheumatoid arthritis. The drug was given for a period of 2 weeks at both dose levels. Significant improvement was noted with both dose levels in pain relief, articular tenderness and grip strength, but no significant differences were noted between the two dosages. An anti-inflammatory effect could not be demonstrated. Five of the 16 patients had to discontinue therapy at the lower dose due to gastric intolerance.

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