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Current Medical Research and Opinion Volume 4, 1976 - Issue 4
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Research Article

Comparison of azapropazone and naproxen in rheumatoid arthritis

Hilary A. Capell The Centre for Rheumatic Diseases, and The University Department of Medicine, Royal Infirmary, Glasgow, Scotland
,
Marion M. McLeod The Centre for Rheumatic Diseases, and The University Department of Medicine, Royal Infirmary, Glasgow, Scotland
,
Luis A. Hernández The Centre for Rheumatic Diseases, and The University Department of Medicine, Royal Infirmary, Glasgow, Scotland
,
David M. Grennan The Centre for Rheumatic Diseases, and The University Department of Medicine, Royal Infirmary, Glasgow, Scotland
&
J. Stewart Templeton The Centre for Rheumatic Diseases, and The University Department of Medicine, Royal Infirmary, Glasgow, Scotland
Pages 285-289 | Received 28 Apr 1976, Published online: 07 Aug 2008
 
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Summary

A double-blind crossover trial was carried out in 15 patients with definite rheumatoid arthritis to compare the effectiveness of 1200 mg azapropazone daily and 750 mg naproxen daily, each drug being given for 2 weeks. Patients also received placebo therapy before and between the two treatment periods. The results of subjective and objective assessments showed that both drugs were significantly superior to placebo, but no significant difference could be demonstrated between the two drugs.

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