A double-blind comparison between meptazinol (Wy 22811) and ‘Buscopan’ Compositum in renal colic

Summary

The analgesic effect of a single intravenous injection of 60 mg. meptazinol or of a spasmolytic-analgesic combination (‘Buscopan’ Compositum: 20 mg. hyoscine-N-butylbromide plus 2.5 g. nor-amidopyrine)was studied in a double-blind trial in 40 patients with acute renal colic. The results showed that meptazinol provided greater pain relief and was faster acting. Pain relief after meptazinol persisted for at least 1 hour in all but 1 of the 20 patients treated. Dizziness was a frequent but well tolerated side-effect of meptazinol, and nausea and vomiting were reported almost equally after both treatments.

Key Words::

• Meptazinol
• analgesics
• hyoscine-N-butylbromide
• colic, renal