Inhibition of nocturnal gastric secretion by trimoprostil, a synthetic prostanoid

Summary

Eleven healthy volunteers had nocturnal gastric secretion studied on three occasions to compare, in a randomized manner, the gastric inhibitory effects of two doses (1.5 and 3.0 mg) of trimoprostil with placebo. Nocturnal gastric secretion of acid was significantly inhibited for 7 hours with the higher dose of the drug, by a total of about 50 percent. The output of pepsin was also reduced, albeit not as markedly as acid, for the first 5 hours of the study. It is concluded that trimoprostil, in the doses used in the present study, is capable of reducing gastric secretion without producing side-effects.

Key Words::

• Trimoprostil
• prostaglandins
• gastric juice
• pepsin