Characterizing the Diurnal Rhythm of DHEA

Elena A Erosheva Elena A. Erosheva is a Doctoral Student, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 . Patricia D. Kroboth is Professor and Chairman, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261 . Joel B. Greenhouse is Professor, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 (Email: . This research was supported by R01-MH55756, and NIH/NCRR/GCRC 5M01RR00056, MH30615 and NIH CA54852. The authors thank Roslyn A. Stone, Howard Seltman, Gretchen L. Haas, Frank J. Kroboth III, and the staff at the Pharmacodynamics Research Center and the General Clinical Research Center at Montefiore University hospital of UPMC-HS.

Patricia D Kroboth Elena A. Erosheva is a Doctoral Student, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 . Patricia D. Kroboth is Professor and Chairman, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261 . Joel B. Greenhouse is Professor, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 (Email: . This research was supported by R01-MH55756, and NIH/NCRR/GCRC 5M01RR00056, MH30615 and NIH CA54852. The authors thank Roslyn A. Stone, Howard Seltman, Gretchen L. Haas, Frank J. Kroboth III, and the staff at the Pharmacodynamics Research Center and the General Clinical Research Center at Montefiore University hospital of UPMC-HS.

Joel B Greenhouse Elena A. Erosheva is a Doctoral Student, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 . Patricia D. Kroboth is Professor and Chairman, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261 . Joel B. Greenhouse is Professor, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 (Email: . This research was supported by R01-MH55756, and NIH/NCRR/GCRC 5M01RR00056, MH30615 and NIH CA54852. The authors thank Roslyn A. Stone, Howard Seltman, Gretchen L. Haas, Frank J. Kroboth III, and the staff at the Pharmacodynamics Research Center and the General Clinical Research Center at Montefiore University hospital of UPMC-HS.

Abstract

Recently, there has been a lot of effort in the scientific community to understand the role of the naturally occurring hormone, dehydroepiandrosterone (DHEA). In order to plan experiments optimally, it is critical first to characterize the diurnal rhythm in healthy individuals. We present an analysis of DHEA concentrations under the framework of linear mixed-effects model. The samples were collected over 23.5 hours on 49 healthy individuals (27 young: 15 men, 12 women; 22 elderly: 12 men, 10 women) under placebo and alprazolam (2 mg oral dose) treatments. The population profiles of diurnal variation of DHEA concentrations, specific to age, sex, and minority status, and the effect of alprazolam on DHEA concentrations are estimated.

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