10T024A, a New Phenazine Derivative, as a Radical Scavenger and a Prostaglandin, Leukotriene Release Suppressor

Abstract

We identified a new radical scavenger, 10T024A (C₁₅H₁₂N₂O₄), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radical-scavenging activity with an ED₅₀ of 125 μM. Moreover, it showed prostaglandin D₂ (PGD₂) and leukotriene B₄ (LTB₄) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC₅₀: 8 μM and 10 μM respectively.

• phenazine
• 2,2-diphenyl-1-picrylhydrazyl (DPPH)
• Streptomyces sp.
• prostaglandin D₂
• leukotriene B₄