We found that stem-cell leukemia (SCL), also known as T cell acute-lymphocytic leukemia (Tal-1) gene expression, was upregulated in the maturing rat testis. Strong expression of Tal-1 was detected in the normal maturing rat testis by Northern blotting. Western blotting revealed the protein size to be about 34 kDa. Protein expression was wide-spread in spermatocytes, spermtids and spermatogonia in accordance with the seminiferous epithelium cycle, as determined by an analysis of immunohistochemistry. Gene expression of Tal-1 regulatory gene, NKX3.1, was negatively correlated with Tal-1 expression. Human Tal-1 expression in the maturing testis as well as in bone marrow was observed, which suggests that the gene product is a novel cancer-testis antigen candidate. Taken together, TAL-1 may be involved in cell division, morphological changes, and the development of spermatogenic cells in the normal rat testis.
Bioscience, Biotechnology, and Biochemistry
Volume 76, 2012 - Issue 11
![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related Research Data
Networking erythropoiesis
Source:
Rockefeller University Press
A novel spermatogenesis related factor-2 (SRF-2) gene expression affected by TCDD treatment.
Source:
Japan Endocrine Society
Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells
Source:
American Society of Hematology
The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages
Source:
Elsevier BV
Dysfunctional spermatogenesis in transgenic mice overexpressing bHLH-Zip transcription factor, Spz1
Source:
Elsevier BV
Cell environment influences TAL1 genomic targeting
Source:
Wiley
Scanlan et al ·Cancer/testis antigens
Source:
Wiley
Expression of small stress protein hsp20 gene in the maturing rat testis.
Source:
Japanese Society of Veterinary Science
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.
Source:
Wiley
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia
Source:
HAL CCSD
Developmental Schedule of the Postnatal Rat Testis Determined by Flow Cytometry
Source:
Oxford University Press (OUP)
Expression of rat sperm flagellum-movement associated protein genes under 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment.
Source:
Oxford University Press (OUP)
Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells
Source:
American Society for Microbiology
Expression of the Centrosomal Colon Cancer Autoantigen Gene during Spermatogenesis in the Maturing Rat Testis
Source:
Oxford University Press (OUP)
Linking provided by
