Biotin is one of the most useful tags in (bio)analytical science due to its specific interaction with avidin, but is not easy to convert because of its low solubility in most solvents. Friedel-Crafts acylation of biotin acid chloride in triflic acid was examined, and the synthesized derivatives had stronger affinity to avidin than biotin in a binding assay using 2-(4'-hydroxyphenylazo)benzoic acid.
Bioscience, Biotechnology, and Biochemistry
Volume 76, 2012 - Issue 11
![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related Research Data
Isolation and properties of streptavidin.
Source:
Elsevier
Introduction to avidin-biotin technology.
Source:
Elsevier
EFFECTIVE SYNTHESIS OF OPTICALLY ACTIVE 3-PHENYL-3-(3-TRIFLUOROMETHYL) DIAZIRINYL BISHOMOPHENYLALANINE DERIVATIVES
Source:
The Japan Institute of Heterocyclic Chemistry
Biotin as acylating agent in the Friedel-Crafts reaction. Avidin affinity of biotinyl derivatives of ferrocene, ruthenocene and pyrene and fluorescence properties of 1-biotinylpyrene.
Source:
Royal Society of Chemistry (RSC)
[74] Spectrophotometric determination of avidin and biotin
Source:
Elsevier
Asymmetric and efficient synthesis of homophenylalanine derivatives via Friedel-Crafts reaction with trifluoromethanesulfonic acid
Source:
Elsevier
[11] Biotinidase
Source:
Elsevier
Synthesis of a Biotin-Derived Alkyne for Pd-Catalyzed Coupling Reactions
Source:
American Chemical Society (ACS)
Linking provided by
