Feeding with Both β-Carotene and Supplemental α-Tocopherol Enhances Type 1 Helper T Cell Activity among Splenocytes Isolated from DO11.10 Mice

Abstract

β-Carotene and/or supplemental α-tocopherol were fed to DO11.10 mice to investigate their effect on the immune function of naive splenocytes. A high secretion of interleukin-12 and interferon-γ in response to the ex vivo primary antigen presentation occurred only when both were fed. This is consistent with the suppressed immunoglobulin E production under the similar condition described in our previous report.

• β-carotene
• α-tocopherol
• antigen presentation
• interleukin-12
• interferon-γ