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Bioscience, Biotechnology, and Biochemistry Volume 68, 2004 - Issue 10
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Original Articles

Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines

Takeshi KAWAHARAIntegrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
,
Daisuke KATAYAMAIntegrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
&
Hajime OTANIIntegrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
Pages 2091-2095 | Received 13 May 2004, Accepted 26 Jul 2004, Published online: 22 May 2014
 
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Abstract

The effect of bovine β-casein (1-28) purified from commercial casein phosphopeptide preparations on human T, B, and monocyte cell lines was evaluated. Beta-casein (1-28) enhanced the proliferation of the following: T cell lines HUT-78, Jurkat Clone E6-1, and MOLT-4; B cell lines BALL, KHM-1B, and U266B1; and monocyte cell lines U937 and HL-60. Moreover, β-casein (1-28) stimulated IgA production by KHM-1B over 96 h of culture. Semiquantitative reverse transcriptional-polymerase chain reaction analysis indicated that β-casein (1-28) enhanced mRNA expression of interleukin (IL)-6 in U266B1 and KHM-1B. These results suggest that β-casein (1-28) exerts a mitogenic effect on human T, B, and monocyte cells, and an IgA-enhancing effect on B cells.

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Related Research Data

Inhibition of Prolyl Endopeptidase by Synthetic β-Casein Peptides and Their Derivatives with a C-Terminal Prolinol or Prolinal
Source: Oxford University Press (OUP)
The Immunoenhancing Property of a Dietary Casein Phosphopeptide Preparation in Mice
Source: Informa UK Limited
Identification of a phosphopeptide in bovine αs1-casein digest as a factor influencing proliferation and immunoglobulin production in lymphocyte cultures
Source: Cambridge University Press (CUP)
Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins
Source: Published by Elsevier B.V.
Effects of Bovine β-Casein (1-28) and Its Chemically Synthesized Partial Fragments on Proliferative Responses and Immunoglobulin Production in Mouse Spleen Cell Cultures
Source: Oxford University Press (OUP)
Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.
Source: Rockefeller University Press
Enhanced Absorption of Calcium by Casein Phosphopeptides in Rachitic and Normal Chicks
Source: Oxford University Press (OUP)
A Peptide Inhibitor of Angiotensin I Converting Enzyme in the Tryptic Hydrolysate of Casein
Source: Oxford University Press (OUP)

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