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ABSTRACT
The effect of fenugreek seeds (Trigonella foenum graecum) compared with ranitidine was studied on aspirin-induced gastric ulcer. The gel fraction isolated from the seeds showed significant ulcer protective effect. The cytoprotective effect of the seeds seemed to be not only due to the anti-secretory action but also due to the effects on mucosal glycoproteins. The fenugreek seed gel also prevented the rise in lipid peroxidation induced by aspirin presumably by enhancing antioxidant potential of the gastric mucosa thereby lowering mucosal injury. Histological studies revealed that the soluble gel fraction prevents lesion formation and is effective as ranitidine. These observations show that fenugreek seeds possess antiulcer potential.