Abstract
This cross sectional descriptive study used Hierarchical regression, with Bronfenbrenner's framework, to examine the ‘system’ factors that significantly predicted substance-using behavior in an African American/Hispanic, non-clinical, convenience sample of urban youth to move beyond individualistic explanations for youth substance use. Participants (N= 98), age 11–17, with self/parent written consent, completed, individually, a ten-page questionnaire. Regression analysis indicated that youth with higher depression scores, perceived primary caregiver problems, and violence exposure tended to report substance use. Parent/school/community prevention efforts might focus assessment/prevention on youth/caregiver depression and family relationships, as they may be crucial protective factors against violent environments, trauma response, and mood-altering substance use.