Pathogenesis of Fibromyalgia

Abstract

The core symptoms and signs of the fibromyalgia [FM] syndrome are generalized chronic pain occurring mainly in muscles and hyperalgesia [tender point]. There is not one single cause to FM. The pathogeneses is a chain of events. Some links in the chain are still missing and some links are weak. The hypothesis presented is that FM is caused by a combination of peripheral factors mainly muscle and central factors. The central factors result in a decrease of pain inhibition.

KEYWORDS:

• Fibromyalgia
• muscle pain