Abstract
Background: The application is in the field of bioimaging and adult neurogenesis. Objective: It aims at correlating the volume of cerebral blood (CBV) in the dentate gyrus (DG) of the human hippocampus, determined by magnetic resonance imaging (MRI), with neurogenesis in the brain of adult rodents. Methods: Adult mice were submitted to voluntary exercise or administration of fluoxetine or valproic acid (VPA). The CBV of DG was determined by MRI and neurogenesis was quantified by immunohistofluorescence. The CBV in human subjects selected and grouped according to their fitness activity was determined by MRI in the DG. Results: A selective increase in the CBV of the DG is observed in rodents housed in activity cages or administered with fluoxetine and VPA. A selective increase in the CBV of the DG is also observed in exercising humans. The selective increase of the CBV in the human DG correlates with the selective increase of the CBV in the DG and neurogenesis induced by exercise or fluoxetine and VPA in rodents. Conclusion: This indicates that neurogenesis is increased in the DG of exercising humans. The application claims the imaging of the DG of patients by MRI as a paradigm to monitor neurogenesis and identify treatments involving stimulation of neurogenesis
Declaration of Interest Statement:
The author declares no financial and competing interests with the subject matter or materials discussed in the manuscript.