368
Views
23
CrossRef citations to date
0
Altmetric
Reviews

Bradykinin receptor antagonists – a review of the patent literature 2005 – 2008

, , , &
Pages 919-941 | Published online: 24 Jun 2009
 

Abstract

Background: For > 20 years, pharmaceutical companies and academic centers have been developing bradykinin antagonists. The patent literature on these molecules (up to and including 2004) has been analyzed previously in this journal in two review articles. Objective: The aim of this review is to provide an update (from 2005 to early 2009) on the patenting activity in the field of bradykinin antagonists (including patents on their formulation). Where possible, the information from the patents has been supplemented with that from the primary literature, clinical trial databases and company websites in an attempt to give a more complete picture. Conclusions: In the past 4 years, nearly 50 new patents have been filed on bradykinin antagonists – in the case of several filings, only the original source has been considered in this analysis – the vast majority of these (> 93%) on B1 antagonists. However, despite this large amount of work, only one compound, icatibant – a hydrophilic decapeptide selective for the B2 receptor – has reached the market, although it needs to be administered parenterally.

Notes

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,757.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.