The role of sulfamide derivatives in medicinal chemistry: a patent review (2006 – 2008)

Abstract

Background: The sulfamide (R₂NSO₂NR₂) functionality is an acceptable functional group in medicinal chemistry when incorporated into putative small-molecule therapeutics, as it has the potential to form several electrostatic interactions with protein and other targets. The clinically-useful broad spectrum antibiotic doripenem contains a mono-substituted sulfamide. The sulfamide functional group is often found to substitute for sulfonamide, sulfamate or urea functionality. Objective/method: During the period of 2006 – 2008, there were nine published patents in which all or most reported compounds contained the sulfamide functional group. There are also patents in which the structures disclosed contain a cyclic sulfamide functional group. Further, there are patents published during this timeframe that contain only a few sulfamide-containing examples, typically as a bioisosteric replacement for a sulfonamide moiety. In this review, we focus on those published patents in which most compounds disclosed are sulfamides and only briefly highlight examples in which sulfamides are included among a large list of other suitable functionalities. Conclusion: While the sulfamide functionality is still fairly under-represented in medicinal chemistry, it is a valuable and versatile group that will gain increasing acceptance and favor in the future.

Keywords::

• acylsulfamides
• anticonvulsant
• bioisostere
• carbonic anhydrase
• chemokine receptor
• endothelin receptor antagonists
• monoamine uptake inhibitors
• potassium channels
• PPAR-α agonists
• sulfamide
• sulfonamide
• therapeutic