Leukotriene B₄ inhibitors: US2009054466; US2009227603 and US2009253684

Abstract

Three US applications describing a narrow, closely related series of antagonists of the action of leukotriene B₄ on the BLT1 and BLT2 receptors are described. The generic structure claimed is a lipophilic linked diphenyl core containing two acid groups appended to the central phenyl ring. The terminal phenyl moiety contains disubstitution at the 3′- and 5′-positions. These three applications differ in the nature of the substituent on the terminal phenyl group as well as the linking moiety between the two phenyl rings. These compounds are claimed to have utility in inflammatory diseases such as severe asthma and chronic obstructive pulmonary disease.

Keywords::

• 5-lipoxygenase
• asthma
• BLT1R
• BLT2R
• cardiovascular disease
• chronic obstructive pulmonary disease
• leukotriene B₄

Notes