NO donors with anticancer activity

Adam J Janczuk Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Qiang Jia Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Ming Xian Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Zhong Wen Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Peng George Wang Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Tingwei Cai Department of Chemistry, Wayne State University, Detroit, MI 48202, USA, Tel: +1 313 993 6759; Fax: +1 313 577 2554;, E-mail: [email protected]

Abstract

Nitric oxide (NO) radicals, endogenously produced from L-arginine or supplied by NO-releasing donors, are involved in numerous physiological and pathological processes. Although there has been rapid growth in NO research, cancer research still remains in its infancy. A few reports suggest that NO has some anticancer properties, yet others implicate NO in tumour promotion. This article will focus on the anticancer activity of NO donors that have been claimed in patents between 1998 and 2001.

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NO donors with anticancer activity

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NO donors with anticancer activity

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