Abstract
A novel depot formulation of magnesium diparecoxib is claimed for parecoxib. An intramuscular injection of magnesium diparecoxib manifested low Cmax and extended plasma half-life for valdecoxib. Benefits of having a depot formulation for parecoxib are discussed with regard to safety and convenience in dosing.
Patent Details
Title Metal salts of parecoxib as prodrugs of the COX-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever
Assignee Pharmacia Corp.
Inventors Wadhwa M, Vick S
Priority date 24/12/2003
Filing date 13/12/2004
Publication date 21/07/2005
Publication no. WO2005065684