Abstract
Imidazo[4,5-c]pyridine analogs with Akt (PKB) kinase antagonist activity are claimed. The compounds contain a 4-amino-1,2,5-oxadiazole substituent at the 2-position of the ring system with an alkyne substituent at the 4-position, and diverse functionality at the 6-position. The compounds are indicated to be useful in the treatment of cancer and arthritis.
Patent Details
Title Inhibitors of Akt activity.
Assignee SmithKline Beecham Corporation.
Inventors Heerding DA, Rouse MB, Seefeld MA.
Priority date 20/04/05.
Filing date 20/04/05.
Publication date 26/10/06.
Publication no. WO2006/113837.