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Expert Opinion on Therapeutic Patents Volume 18, 2008 - Issue 9
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Patent Evaluation

Pfizer's dual-acting β2 agonists/muscarinic M3 antagonists

Pfi zer: WO2008041095

Peter Norman Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK [email protected]
, MBA PhD
Pages 1091-1096 | Published online: 21 Aug 2008
 
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Abstract

Bifunctional aromatic compounds that contain both β2 agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to both activities and appear designed to provide a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease.

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