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Summary
Novelty: A nonapeptide sequence of human lipocortin V (residues 204-212) is claimed to have anti-inflammatory properties and be useful for dermatological and collagen inflammatory conditions.
Biology: Data are presented which indicate that the peptide can inhibit PGE2 release from rat leukocytes and human fibroblasts (94% inhibition at 100 μg/ml), inhibit PLA2-induced contractions in rat stomach strip (60% at 20 μg/ml), inhibit PLA2-induced oedema in rat paw in vivo and of carrageenin-induced oedema in rat paw (37% inhibition at 4 hours with 2 mg/kg).
Chemistry: The peptide is synthesized by solid phase methodology and has the structure given below.
Structure: 