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Expert Opinion on Therapeutic Patents Volume 22, 2012 - Issue 2
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Patent Evaluations

Compositions and methods for treatment of Parkinson's disease: a patent evaluation of WO2011/102847A1

Valerio ChiurchiùLaboratorio di Neurochimica dei Lipidi, Centro Europeo di Ricerca sul Cervello (CERC) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy
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Mauro MaccarroneLaboratorio di Neurochimica dei Lipidi, Centro Europeo di Ricerca sul Cervello (CERC) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy;Dipartimento di Scienze Biomediche Comparate, Università di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
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Antonio OrlacchioLaboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello (CERC) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy+39 06 501703308; +39 06 501703312; [email protected];Dipartimento di Neuroscienze, Università di Roma “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy
Pages 181-184 | Published online: 18 Jan 2012
 
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Abstract

Background: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD).

Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for the treatment of PD.

Methods: mDA neurons were produced from neural progenitor cells or stem cells by activating both the Wnt-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways.

Results: The level of the proteins of these two synergic pathways is increased, as well as their biological activity.

Conclusion: The invention provides a method for treating or preventing PD by increasing the level of at least one protein involved in an autoregulatory pathway, which is fundamental during mDA neurons differentiation.

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