Quinoxaline derivatives: a patent review (2006 – present)

Abstract

Introduction: Quinoxaline scaffold is included in a large number of therapeutic agents because of its physicochemical properties that make the difference between them and the carbono analogue, naphthalene.

Areas covered: This review of patented products presents the quinoxaline heterocycle as part of the structural patent claims from a medicinal chemistry perspective.

Expert opinion: We centred our discussion in the various drug patent applications of the quinoxaline and its derivatives. The applications are based firstly in the specific enzyme target with very low development in the disease treatment. Only for cancer and antimicrobial agents they were specifically determined but little is mentioned in order to insight in the last development activities.

Keywords::

• bioactive quinoxaline
• benzo[b][1,4]diazine
• quinoxaline
• quinoxaline dioxide,
• quinoxaline monooxide

Acknowledgment

The authors thank PEDECIBA, ANII and CSIC-UdelaR.

Notes

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